Article: Colon cancer, adenoma carcinoma and serrated polyp sequence

SUMMARY

Adenomatous polyps are very common and have great potential for malignancy. Of these, the virus is the one with the greatest malignant potential, but all histological types have a hairy component in greater or lesser proportion, so that they can all be considered premalignant, this degenerative process known as adenoma carcinoma85% of colorectal cancers. Today, thanks to technological advances, it is known that not all colorectal cancers present the aforementioned sequence, the remaining 10 to 15%, are included in the so-called "Serrated neoplasia pathway" whose characteristic is the instability of micro satellites, characterized by the inactivation of DNA repair genes by epigenetic changes such as hypermethylation of the promoter of the MLH1 gene observed in Lynch syndrome.